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National Institutes of Health

Eunice Kennedy Shriver National Institute of Child Health and Human Development

2017 Annual Report of the Division of Intramural Research

Message from Constantine A. Stratakis, MD, D(med)Sci

Constantine Stratakis

Our 2017 annual report of the Division of Intramural Research (DIR) for the Eunice Kennedy Shriver National Institute of Child Health and Human Development is now available to you electronically, either on the web and on your cell phones or tablets, at:

We invite you to look through the report site, to review our medical and scientific discoveries of the past year, to see what work a colleague may currently be engaged in, or to identify a laboratory where you may wish to collaborate or refer a student. For potential postdoctoral fellows, graduate students, and clinical fellows, the report is fully searchable. It offers you an introduction to a panoply of research endeavors in NICHD’s DIR.

NICHD intramural investigators comprise a broad array of basic, translational, and clinical researchers. Our work is reflected in our mission statement:

“To plan and conduct the Institute’s laboratory and clinical research programs to seek fundamental knowledge about the nature and behavior of living systems through basic, clinical, and population-based research and determine how to apply such knowledge to illuminate developmental origins of health and disease and help ensure that women and men have good reproductive health, that children are born healthy, and that people develop to live healthy and productive lives.”

We use a range of model systems in the areas of developmental biology, molecular and cellular biology, neurosciences, structural biology, imaging, behavior, and biophysics. Investigators take advantage of our resources in a 19,000-tank zebrafish core facility and working with a number of other animal models, from fruit flies to rats and mice, and supported by a wide array of core services, including imaging, proteomics and molecular genomics. Each investigator participates in at least one, and typically more, affinity groups. These affinity groups are team-based and future-oriented—to build on thematic interests while responding to rapidly shifting scientific priorities as new knowledge is uncovered.

I invite you to read through the selection of our Clinical Research Protocols listed in this report and to consider how we may collaborate, through the NIH U01 grant mechanism at the NIH Clinical Research Center. The support of this program can lead to our next new success in therapeutics, the next miracle drug, if we combine expertise, take advantage of our NIH infrastructure and our patient population, whether on rare disorders or the most persistent problems affecting human health.

The DIR researchers whose names appear in this publication are committed to training the next generation of scientists and physician scientists; they include tenure-track investigators who have recently joined us and accomplished investigators who continue to forge new scientific paths. Link to their reports on the web to learn about their work in 2017. I also invite you to reach out to me with your ideas and proposals for collaborative initiatives we may undertake together, at

Our drive and purpose, on behalf of the American public and the international community, is to strive to uncover fundamental answers to our existence, whether the basic science that underpins life or the complexities of human health and disease. This is our privilege and responsibility to our chosen professions.

Sincerely yours,
Constantine A. Stratakis, MD, D(med)Sci
Scientific Director, NICHD, NIH

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